Microwave Assisted Synthesis of Py-Im Polyamides

نویسندگان

  • James W. Puckett
  • Joshua T. Green
  • Peter B. Dervan
چکیده

Microwave synthesis was utilized to rapidly build Py-Im polyamides in high yields and purity using Boc-protection chemistry on Kaiser oxime resin. A representative polyamide targeting the 5'-WGWWCW-3' (W = A or T) subset of the consensus Androgen and Glucocorticoid Response Elements was synthesized in 56% yield after 20 linear steps and HPLC purification. It was confirmed by Mosher amide derivatization of the polyamide that a chiral α-amino acid does not racemize after several additional coupling steps.

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عنوان ژورنال:

دوره 14  شماره 

صفحات  -

تاریخ انتشار 2012